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May 8, 2026International Journal of Eating Disorders

Clinical Phenotypes and Neurobiology of Youth With Avoidant/Restrictive Food Intake Disorder ( ARFID ) Across Sex

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Authors

EGEthiopia GetachewMWMarie‐Louis WronskiAWAvery L. Van De Water

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Overview

Randomized trial explores clinical traits and neurobiology of ARFID in youth, indicating no sex-based differences.

Key Points

  • This research aims to investigate sex differences in clinical phenotypes and neurobiological responses in youth with ARFID.
  • Recruited 96 children and adolescents with ARFID and sub-threshold ARFID (49% female).
  • Analyzed clinical phenotypes, appetite-regulating hormones, and fMRI activation during food cue paradigms.
  • Employed frequentist and Bayesian statistical analyses to assess data.
  • No significant sex differences were found in frequency of ARFID clinical phenotypes.
  • No differences in levels of appetite-regulating hormones were observed between males and females.
  • No variation in brain activation in cognitive control and reward-related regions was detected.

Cite This Study

Getachew et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e79bfa21ec5bbf06ba3https://doi.org/10.1002/eat.70081
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical profiles of ARFID compared with anorexia and bulimia in young people: a systematic review and meta-analysis2026
  2. 2Psychological and Sociological Influences Contributing to Avoidant Restrictive Food Intake Disorder (ARFID) Across Age Groups and Gender2024 · 3 citations
  3. 3Neurobiological and cognitive correlates of avoidant restrictive food intake disorder (ARFID): a systematic review2026
  4. 4Associations Between Avoidant/Restrictive Food Intake Disorder Dimensions and Obsessive‐Compulsive Symptomatology2026 · 1 citations
  5. 5Avoidant restrictive food intake disorder: recent advances in neurobiology and treatment2024 · 56 citations