PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
May 8, 2026Scientific ReportsOpen Access

Genetic susceptibility and gene–environment interactions in gastric cancer among ethnic populations of Northeast India

View Full Paper
Ask AI
Bookmark
Share

Authors

KDKangjam Rekha DeviDMDebdutta MukherjeeSPSanjib Phukan

Discussion

Loading...

Member takes

Overview

Case-control study examines gastric cancer risk factors in Northeast India, suggesting tailored prevention strategies.

Key Points

  • This study aims to identify genetic and lifestyle factors contributing to gastric cancer risk in specific ethnic populations of Northeast India.
  • Case-control study with 190 gastric cancer patients and 317 healthy controls
  • PCR-based genotyping of key genetic markers
  • Assessment of lifestyle factors, including diet and Helicobacter pylori infection
  • GSTM1 null genotype increased gastric cancer risk (adjusted OR 2.26, 95% CI 1.49–3.43; p<0.001)
  • Among tobacco chewers, GSTM1-null genotype significantly raised risk (adjusted OR 12.63, 95% CI 3.04–52.42; p<0.001)
  • Regular consumption of protective foods reduced gastric cancer risk by 40–70%

Cite This Study

Devi et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e90bfa21ec5bbf06d85https://doi.org/10.1038/s41598-026-50133-w
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gastric cancer epidemiology in the Adi tribe of Arunachal Pradesh, India: An ethnic-specific risk factors study2026
  2. 2Genomic susceptibility to gastric cancer in Northwest Iran: population-based and case–control studies2024 · 1 citations
  3. 3Association of Glutathione S-transferase Gene Polymorphisms With Hepatocellular Carcinoma in Patients From Maharashtra, India2026
  4. 4Genetic Polymorphisms in the Glutathione S-transferase Gene With the Association of Lung Cancer: A Hospital-Based Case-Control Study in Southwestern Maharashtra2026
  5. 5Null polymorphism of the GSTM1 and GSTT1 genes in susceptibility to colorectal tumorigenesis: systematic review with meta-analysis2024