Enabling Gradient Biomineralization and Prestress with a Macroscopic Matrix: The Fish Swim Bladder for Bioprocessing-Inspired Fabrication

Key Points

• The aim is to explore the fish swim bladder (FSB) as a natural scaffold for replicating bone-like biomineralization.
• Introduced fish swim bladder as a collagen scaffold for macroscopic applications.
• Examined its potential for creating gradient biomineralization.
• Utilized bioprocessing-inspired techniques for material fabrication.
• FSB demonstrated effective hierarchical mineralization comparable to bone structure.
• Enhanced prestress quality in fabricated materials derived from FSB.
• Results suggest promising applications for advanced material development.