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November 21, 2018Frontiers in Physiology287 citationsOpen Access

Emerging Roles of the Membrane Potential: Action Beyond the Action Potential

LKLina Abdul KadirMSMichael W. StaceyRBRichard Barrett‐Jolley

Key Points

  • This research aims to explore the various roles of membrane potential beyond traditional excitability.
  • Analysis of cellular processes influenced by membrane potential, including cell cycle, proliferation, and muscle contraction.
  • Evaluation of drug modulation on the resting membrane potential to assess therapeutic targets for diseases.
  • Dynamic membrane potential plays a critical role in processes like cell cycle and wound healing, not just excitability.
  • Modulation of the resting membrane potential could open pathways for developing new drugs for cancer and stem cell therapies.

Abstract

about excitability, the data show that in fact excitability is only a small part of it. Emerging evidence show that a dynamic membrane potential is critical for many other processes including cell cycle, cell-volume control, proliferation, muscle contraction (even in the absence of an action potential), and wound healing. Modulation of the RMP is therefore a potential target for many new drugs targeting a range of diseases and biological functions from cancer through to wound healing and is likely to be key to the development of successful stem cell therapies.

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Cite This Study

Kadir et al. (2018) studied this question.

synapsesocial.com/papers/69fdcfb98e1e5e8b19272798https://doi.org/10.3389/fphys.2018.01661
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