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May 9, 2026Organic Letters0 citationsOpen Access

Total Chemical Synthesis of the Human Milk Oligosaccharide Disialyllacto- N -tetraose and Its Degradation by Bifidobacterium bifidum Sialidases

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MTMaiko TanaseANAruto NakajimaNKNaoko Komura

Key Points

  • The research aims to achieve total chemical synthesis of disialyllacto-n-tetraose and investigate its degradation by specific sialidases.
  • Conducted total chemical synthesis of disialyllacto-n-tetraose.
  • Analyzed the degradation process by isolating sialidases from bifidobacterium bifidum.
  • Successfully synthesized disialyllacto-n-tetraose using a total chemical approach.
  • Observed significant degradation of synthesized oligosaccharide by bifidobacterium bifidum sialidases.

Abstract

Disialyllacto-

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Cite This Study

Tanase et al. (2026) studied this question.

synapsesocial.com/papers/69fed008b9154b0b82876fb6https://doi.org/10.1021/acs.orglett.6c01473
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