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Synapse
May 9, 2026JAMA1 citations

One-Year Mortality Among Opioid Overdose Survivors

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RKRobert A. KleinmanSLSarah LarneyNSNaheemot Olaoluwa Sule

Key Points

  • Assess one-year mortality rates among opioid overdose survivors in Ontario, focusing on risks following fentanyl exposure.
  • Utilized Canadian administrative data for analysis.
  • Assessed mortality rates over a one-year period post-overdose.
  • Characterized risk factors associated with postoverdose mortality.
  • Significant mortality risk observed among opioid overdose survivors within the year post-event.
  • Increased risk characterized by the presence of fentanyl in overdose incidents.

Abstract

This study uses Canadian administrative data to evaluate 1-year mortality among opioid overdose survivors in Ontario, Canada, and characterize postoverdose mortality risk after the widespread availability of fentanyl.

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Cite This Study

Kleinman et al. (2026) studied this question.

synapsesocial.com/papers/69fed0abb9154b0b82877c76https://doi.org/10.1001/jama.2026.6469
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies2017 · 1,826 citations
  2. 2Fentanyl, carfentanil and other fentanyl analogues in Canada’s illicit opioid supply: A cross-sectional study2024 · 31 citations
  3. 3Emergency Department–Initiated Buprenorphine for Opioid Use Disorder2026 · 8 citations
  4. 4Emergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence2015 · 917 citations
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