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January 25, 2019Proceedings of the National Academy of Sciences385 citationsOpen Access

Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS–SOS1 interaction

RHR.C. HilligBSBrice SautierJSJens Schroeder

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Abstract

of 21 nM and is a valuable chemical probe for future investigations.

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Hillig et al. (2019) studied this question.

synapsesocial.com/papers/69ff76cf10d6befb25774822https://doi.org/10.1073/pnas.1812963116
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