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February 8, 2023Journal of Neuroinflammation43 citationsOpen Access

Melanophages give rise to hyperreflective foci in AMD, a disease-progression marker

SASébastien AugustinMLMarion LamSLSophie Lavalette

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Abstract

-mice in vivo, and are associated with RPE dysmorphia similar to intermediate AMD. Finally, we show that Cd47 expression in human RPE declines with age and in AMD, which likely participates in melanophage formation and RPE decline. Boosting CD47 expression in AMD might protect RPE cells and delay AMD progression.

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Augustin et al. (2023) studied this question.

synapsesocial.com/papers/69ff7b38ef3c2ddc5d85118ahttps://doi.org/10.1186/s12974-023-02699-9
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