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August 29, 2018Nutrition & Metabolism41 citationsOpen Access

PPARγ/Pgc-1α-Fndc5 pathway up-regulation in gastrocnemius and heart muscle of exercised, branched chain amino acid diet fed mice

NANavid AbedpoorFTFarzaneh TaghianKGKamran Ghaedi

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Abstract

BACKGROUND: genes in gastrocnemius muscle and heart tissue of male C57BL/6 mice. METHODS: Thirty-six young male mice with an average weight of 18 ± 2 g were selected. Mice were randomly assigned to 6 groups: 20 mg/mL of BCAAs consumption with simultaneous exercise-training, 60 mg/mL of BCAAs consumption with simultaneous exercise-training, exercise-trained with no BCAAs consumption group, 20 mg/mL BCAAs without exercise-training, 60 mg/mL BCAAs without exercise-training, and untrained mice without BCAAs consumption. RESULTS: < 0.05). Two-way analysis of variance (ANOVA) was used to examine significant difference between groups and sedentary group. CONCLUSIONS: gastrocnemius muscle similar with counterparts in heart tissue. Of note, higher serum irisin levels were detected after 20 mg/mL BCAAs supplementation coincided with the exercise. GRAPHICAL ABSTRACT: An Overview on supplemantaion of branched chain amoinoacids on metablism of skeletal muscle and heart.

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Abedpoor et al. (2018) studied this question.

synapsesocial.com/papers/69ff9be8e4618ba4162d85fahttps://doi.org/10.1186/s12986-018-0298-3
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