Shigella flexneri producing OXA-181 was detected from a patient in Ireland in October 2025. The isolate had a meropenem minimum inhibitory concentration (MIC) of 0.12 mg/L. Carbapenemase production was detected by lateral flow immunoassay. The sequence type was ST245 and closely related to sequences previously reported from Ireland and other countries but not previously linked to presence of the bla OXA-181 gene . Carbapenemase production in Shigella spp. has implications for laboratory detection and empiric treatment.
Clarke et al. (2026) studied this question.