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May 10, 2026Small0 citations

Nicotinamide Mononucleotide Ameliorates Nano‐Aluminum Oxide‐Induced Cognitive Impairment and Ferroptosis via the GSH/GPX4 Axis

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LYLei YuTZTao ZhangXLXiaoming Lou

Key Points

  • This research aims to evaluate the protective effects of nicotinamide mononucleotide against cognitive impairment and neuronal injury caused by nano-aluminum oxide.
  • Examined the effects of nicotinamide mononucleotide on cognitive impairment and neuronal injury
  • Analyzed the role of the GSH/GPX4 axis in mitigating ferroptosis
  • Utilized animal models to assess neurotoxicity from nano-aluminum oxide
  • Nicotinamide mononucleotide significantly improved cognitive function as measured by behavioral tests
  • Reduced markers of ferroptosis and restored GSH/GPX4 axis activity
  • Demonstrated protective effects in neuronal injury models, linking NMN treatment to cognitive recovery

Abstract

-induced neurotoxicity is associated with dysregulation of the GSH/GPX4 axis and that NMN protects against cognitive impairment and neuronal injury, at least in part, by suppressing ferroptosis-related processes.

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Cite This Study

Yu et al. (2026) studied this question.

synapsesocial.com/papers/6a002222c8f74e3340f9d268https://doi.org/10.1002/smll.202508100
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