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May 1, 1995Journal of the American Chemical Society154 citations

Toward the Accurate Modeling of DNA: The Importance of Long-Range Electrostatics

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DYDarrin M. YorkWYWeitao YangHLHsing Lee

Key Points

  • Determine the impact of incorporating long-range electrostatic interactions on the accuracy and structural stability of DNA computer simulations.
  • Simulated nucleic acid structures using computational molecular dynamics methods with varied treatments of electrostatic forces.
  • Accounting for long-range electrostatics maintains stable and biologically accurate DNA conformations throughout molecular simulations.
  • Neglecting or truncating long-distance electrical forces introduces severe structural distortions and artifacts in simulated nucleic acids.

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTToward the Accurate Modeling of DNA: The Importance of Long-Range ElectrostaticsDarrin M. York, Weitao Yang, Hsing Lee, Tom Darden, and Lee G. PedersenCite this: J. Am. Chem. Soc. 1995, 117, 17, 5001–5002Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/ja00122a034https://doi.org/10.1021/ja00122a034research-articleACS PublicationsRequest reuse permissionsArticle Views325Altmetric-Citations155LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

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Cite This Study

York et al. (1995) studied this question.

synapsesocial.com/papers/6a003374e92f4a033c85401dhttps://doi.org/10.1021/ja00122a034
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