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September 9, 2003Science2,486 citationsOpen Access

Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China

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YGYi GuanBZBingxue ZhengYHYuxian He

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Abstract

A novel coronavirus (SCoV) is the etiological agent of severe acute respiratory syndrome (SARS). SCoV-like viruses were isolated from Himalayan palm civets found in a live-animal market in Guangdong, China. Evidence of virus infection was also detected in other animals (including a raccoon dog, Nyctereutes procyonoides) and in humans working at the same market. All the animal isolates retain a 29-nucleotide sequence that is not found in most human isolates. The detection of SCoV-like viruses in small, live wild mammals in a retail market indicates a route of interspecies transmission, although the natural reservoir is not known.

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Guan et al. (2003) studied this question.

synapsesocial.com/papers/6a00531c2ff633f36577e3eehttps://doi.org/10.1126/science.1087139
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