Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy

Human induced pluripotent stem (iPS) cell-derived cardiac microtissues and cardiomyocytes

Titin gene variants (TTN-truncating variants and missense mutations)

Pathogenicity of titin gene variants, including contractile performance, sarcomere insufficiency, responses to mechanical and β-adrenergic stress, and cell signaling activationsurrogate