Does unilateral stellate ganglion stimulation or ablation alter the electrocardiogram and ventricular refractory period in open chest dogs?
The study demonstrates regional differences in sympathetic innervation of the ventricles, providing a functional explanation for electrocardiographic abnormalities observed in patients with central nervous system lesions.
Changes of the electrocardiogram and of ventricular refractory period were measured following either unilateral stellate ganglion stimulation or ablation in the open chest dog preparation. Right stellate ganglionectomy or left stellate stimulation produces prolonged Q-T intervals and increased T-wave amplitude. Left stellate ganglionectomy or right stellate stimulation produces increased T-wave negativity without measurable change in the Q-T interval. The differing patterns of electrocardiographic wave form resulting from changes in sympathetic tone mediated by right and left stellate innervation could be correlated with changes in ventricular refractory period. Following right stellate ganglionectomy, refractory period prolongations were most marked over the anterior ventricular surface; left stellate ganglionectomy produced the greatest prolongation on the posterior surface. Although the right and left stellate innervations of the ventricles overlap, the left stellate influence is predominant over the posterior wall of the ventricles, while right stellate influence dominates the anterior ventricular walls. The electrocardiographic form changes observed following unilateral alteration of sympathetic tone paralleled those electrocardiographic abnormalities seen in patients with lesions of the central nervous system, suggesting a possible functional explanation for these clinical findings.
Yanowitz et al. (1966) studied this question.