ABSTRACT Metastasising ameloblastoma (MA) is a rare odontogenic tumour with an unpredictable natural history, capable of presenting decades after primary resection. Pulmonary involvement is the most common site of distant spread; however, endobronchial disease‐causing airway obstruction and haemoptysis is exceptionally rare, with very few cases reported in the literature. Existing reports describe modest and short‐lived responses to endobronchial therapy, with rapid recurrence. We report a case of bilateral endobronchial MA presenting 31 years after mandibular resection, where surgical intervention was not feasible and systemic therapy was declined by the patient. A multimodal bronchoscopic approach combining bronchial artery embolization, cryodebulking, and airway stenting achieved sustained airway patency and symptom control, with no tumour ingrowth at nearly 1 year. This case challenges the perception that endobronchial MA carries a uniformly poor bronchoscopic response and demonstrates that interventional pulmonology techniques can offer meaningful and durable palliation in this rare condition.
Parrikar et al. (2026) studied this question.