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April 23, 2015Scientific Reports182 citationsOpen Access

Antibacterial activity of silver-killed bacteria: the "zombies" effect

RBRacheli Ben‐KnazRPRami PedahzurDADavid Avnir

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Abstract

We report a previously unrecognized mechanism for the prolonged action of biocidal agents, which we denote as the zombies effect: biocidally-killed bacteria are capable of killing living bacteria. The concept is demonstrated by first killing Pseudomonas aeruginosa PAO1 with silver nitrate and then challenging, with the dead bacteria, a viable culture of the same bacterium: Efficient antibacterial activity of the killed bacteria is observed. A mechanism is suggested in terms of the action of the dead bacteria as a reservoir of silver, which, due to Le-Chatelier's principle, is re-targeted to the living bacteria. Langmuirian behavior, as well as deviations from it, support the proposed mechanism.

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Cite This Study

Ben‐Knaz et al. (2015) studied this question.

synapsesocial.com/papers/6a01a60060baf37e2cd8b359https://doi.org/10.1038/srep09555
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