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October 1, 1976Journal of General Virology370 citations

Inhibition of Influenza Virus Replication in Tissue Culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): Mechanism of Action

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PPPeter PaleseRCRichard W. Compans

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Abstract

The neuraminidase inhibitor 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA) inhibits the mutlicycle replication of influenza viruses in tissue culture. Influenza virus grown in the presence of FANA contains neuraminic acid on its envelope which then serves as receptor for other virus particles causing extensive aggregation. Thus, FANA inhibits influenza virus replication by preventing the enzymatic removal of neuraminic acid from the virus envelope.

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Palese et al. (1976) studied this question.

synapsesocial.com/papers/6a0214a3e8ec6bd19dcb1afchttps://doi.org/10.1099/0022-1317-33-1-159
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Inhibition of Viral Neuraminidase As a New Approach to the Prevention of Influenza* *This work was monitored by the Commission on influenza of the Armed Forces Epidemiological Board, and was supported (in part) by the U. S. Army Medical Research and Development Command under research contract No. DADA1769-C-9137, by Public Health Service research grant No. AI09304 from the National Institute of Allergy and Infectious Diseases, and by contract No. U-2076 from the Health Research Council of the City of New York.1975 · 16 citations
  2. 2Isolation and Preliminary Characterization of Temperature-Sensitive Mutants of Influenza Virus1972 · 117 citations
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