Adding aspirin to warfarin did not significantly reduce the primary atherothrombotic composite endpoint compared to warfarin alone in Japanese patients with mechanical valve replacement (22.0% vs 13.7%, P=0.13).
Does aspirin added to warfarin improve outcomes in Japanese patients with mechanical valve replacement?
The observations support a cautious, indication-driven approach in which aspirin is used selectively as an adjunct to warfarin rather than as a default strategy in Japanese patients with mechanical valves.
Absolute Event Rate: 22% vs 13.7%
p-value: p=0.13
Nobuaki Tanaka (2026) conducted an editorial in Mechanical valve replacement (n=158). Warfarin plus aspirin vs. Warfarin alone was evaluated on Atherothrombotic composite including cardiovascular death (p=0.13). Adding aspirin to warfarin did not significantly reduce the primary atherothrombotic composite endpoint compared to warfarin alone in Japanese patients with mechanical valve replacement (22.0% vs 13.7%, P=0.13).