PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
March 31, 2026Trends in Endocrinology and Metabolism0 citations

The reciprocal endothelium-adipose loop fuels cardiometabolic diseases

View Full Paper
CCCheng ChSOS. OffermannsYHYu Huang

Key Result

Recent studies establish a reciprocal crosstalk between the endothelium and adipose tissue in obesity, linking their respective pathologies and motivating multimechanism therapies for cardiometabolic diseases.

Key Points

  • This research aims to understand the interplay between endothelium and adipose tissue in cardiometabolic diseases.
  • Analysis of the dynamic interactions between vasculature and adipose tissue.
  • Examination of 'endothelium-to-adipose' and 'adipose-to-endothelium' pathways.
  • Identified a self-perpetuating cycle in obesity affecting cardiometabolic health.
  • Proposed multimechanism therapies targeting both endothelial and adipose pathology.

PICO

P
Population
cardiometabolic diseases

Abstract

Vasculature and surrounding adipose tissue constitute a dynamic interface, maintaining cardiometabolic homeostasis. Obesity rewires this crosstalk into a self-perpetuating cycle. Two recent studies by Suda et al. and Hof et al., respectively, established the 'endothelium-to-adipose' and 'adipose-to-endothelium' arms, linking endothelial and adipose pathology and motivating multimechanism therapies for cardiometabolic diseases.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Ch et al. (2026) conducted an editorial in cardiometabolic diseases. Recent studies establish a reciprocal crosstalk between the endothelium and adipose tissue in obesity, linking their respective pathologies and motivating multimechanism therapies for cardiometabolic diseases.

synapsesocial.com/papers/6a025ca5edf6f48138594833https://doi.org/10.1016/j.tem.2026.01.005
Ask AI
Helpful
Bookmark
Share
View Full Paper

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice2025 · 19 citations
  2. 2Exercise protects aged mice against coronary endothelial senescence via FUNDC1-dependent mitophagy2023 · 65 citations
  3. 3Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes2025 · 57 citations
  4. 4Endothelial lipid droplets drive atherosclerosis and arterial hypertension2024 · 25 citations
  5. 5Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites2024 · 25 citations