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May 12, 2026Organic Letters0 citations

Palladium-Catalyzed Domino Reaction of 2-Alkynylanilines with 2-Ethynylaziridines─Access to Indole and Carbazole Derivatives

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WHWei-Tao HuUniversity of Science and Technology of ChinaHJHong-Xia JiangUniversity of Science and Technology of ChinaXXXian XiaoUniversity of Science and Technology of China

Key Points

  • The aim is to explore a palladium-catalyzed reaction for synthesizing indole and carbazole derivatives.
  • Utilized -tosyl-2-(arylethynyl)anilines and 2-ethynylaziridines in the reaction.
  • Conducted the reaction at 80 °C.
  • Isolated carbazole derivatives through intermediates.
  • Successfully synthesized carbazole derivatives from 2-alkynylanilines.
  • Formation of 3-allenylindole intermediates observed during the reaction.

Abstract

-tosyl-2-(arylethynyl)anilines with 2-ethynylaziridines under the same catalysis conditions at 80 °C gives carbazole derivatives via the 3-allenylindole intermediates.

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Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/6a02c2fdce8c8c81e964055chttps://doi.org/10.1021/acs.orglett.6c01373
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