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May 23, 2019Haematologica45 citationsOpen Access

High activation of STAT5A drives peripheral T-cell lymphoma and leukemia

BMBarbara MaurerHNHarini NivarthiBWBettina Wingelhofer

Key Points

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Abstract

We conclude that enhanced STAT5A or STAT5B action both drive PTCL development, defining both STAT5 molecules as targets for therapeutic intervention.

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Cite This Study

Maurer et al. (2019) studied this question.

synapsesocial.com/papers/6a0317b067f6ea5cc8757edchttps://doi.org/10.3324/haematol.2019.216986
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Also Consider

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  1. 1Distinct Effects of STAT5 Activation on CD4+ and CD8+ T Cell Homeostasis: Development of CD4+CD25+ Regulatory T Cells versus CD8+ Memory T Cells2003 · 211 citations
  2. 2Memory T and memory B cells share a transcriptional program of self-renewal with long-term hematopoietic stem cells2006 · 294 citations
  3. 3Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma2003 · 73 citations
  4. 4Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein2014 · 62 citations
  5. 5Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia2012 · 777 citations