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May 13, 2026Journal of Medicinal Chemistry0 citations

Identification of an Hsp110/HDAC6 Dual-Target Inhibitor for the Effective Treatment of Pulmonary Arterial Hypertension via Synergistic Blockade of Vascular Remodeling

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MLMengqi LiYWYue WangXLXinru Liang

Key Points

  • This research aims to explore a dual-target inhibitor for treating pulmonary arterial hypertension by blocking vascular remodeling.
  • Identified an Hsp110/HDAC6 dual-target inhibitor
  • Assessed its effects on vascular remodeling
  • Analyzed the compounds' potential in pulmonary arterial hypertension.
  • Demonstrated enhanced suppressive effects on vascular remodeling
  • Offered a promising lead compound for PAH treatment

Abstract

demonstrated enhanced suppressive effects on vascular remodeling through synchronous regulation of dual targets. In summary, the present study provides novel research insights into developing novel PAH drugs based on antivascular remodeling strategies and offers a promising lead compound.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a03cbe01c527af8f1ecfa74https://doi.org/10.1021/acs.jmedchem.6c00066
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Endothelin receptor antagonists in pulmonary arterial hypertension2008 · 235 citations
  2. 2Allosteric site identification, virtual screening and discovery of a sulfonamide Hsp110-STAT3 interaction inhibitor for the treatment of hypoxic pulmonary arterial hypertension2024 · 9 citations
  3. 3Design and Optimization of LOXL2 and sGC Dual-Target Regulators Targeting Extracellular Matrix Dysregulation and Vasodilation for the Treatment of Pulmonary Arterial Hypertension2025 · 5 citations
  4. 4Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives2020 · 39 citations
  5. 5Inhibition of Hsp110-STAT3 interaction in endothelial cells alleviates vascular remodeling in hypoxic pulmonary arterial Hypertension model2023 · 25 citations