Creatine ameliorates the adverse effects of high-fat diet on hepatic lipid metabolism, intestinal health, muscle growth and flesh quality in juvenile largemouth bass (Micropterus salmoides)

-oxidation. Notably, this study also reveals a previously undisclosed effect of creatine supplementation on improving muscle quality. Together, for the first time from a comprehensive multiorgan or tissue perspective, our study provides a feasible approach for developing appropriate nutritional strategies to alleviate the adverse effects of HFD on farmed fish, based on creatine supplementation.