The index of microcirculatory resistance accurately predicted left ventricular function recovery (AUC 0.89; 95% CI 0.888-0.894) and correlated with myocardial viability (r = -0.738, P<0.001).
Observational (n=40)
Does the index of microcirculatory resistance (IMR) predict myocardial viability and left ventricular function recovery in patients with anterior AMI after primary PCI?
The index of microcirculatory resistance measured immediately after primary PCI is a reliable early predictor of myocardial viability and left ventricular recovery in patients with anterior AMI.
Effect estimate: AUC 0.89 (95% CI 0.888-0.894)
AIMS: The aim of this study is to evaluate the usefulness of the index of microcirculatory resistance (IMR) for predicting myocardial viability and left ventricular (LV) function recovery in acute myocardial infarction (AMI). METHODS AND RESULTS: After successful primary percutaneous coronary intervention in 40 patients with anterior AMI, IMR was measured using a pressure-temperature sensor-tipped coronary guidewire. Myocardial viability was quantified by 18F-fluorodeoxyglucose (FDG) positron emission tomography in 38 patients. Echocardiographic regional wall motion was analysed to calculate the anterior wall motion score (A-WMS) and percent change in A-WMS after revascularization and at 6-month follow-up. IMR correlated significantly with regional myocardial FDG uptake (r = -0.738, P < 0.001) and it demonstrated significant correlation with percent change in A-WMS (r = -0.464, P = 0.003). The area under the receiver operating curve of IMR for predicting LV function recovery was 0.89 95% CI 0.888-0.894. CONCLUSION: Index of microcirculatory resistance, a new index representing microvascular integrity, is a reliable early on-site determinant of myocardial viability and LV recovery after primary stenting for AMI.
Lim et al. (2009) conducted an observational in Anterior acute myocardial infarction (n=40). Index of microcirculatory resistance (IMR) was evaluated on Prediction of left ventricular function recovery (AUC 0.89, 95% CI 0.888-0.894). The index of microcirculatory resistance accurately predicted left ventricular function recovery (AUC 0.89; 95% CI 0.888-0.894) and correlated with myocardial viability (r = -0.738, P<0.001).