Preoperative BNP levels strongly predicted 30-day perioperative complications in cardiac patients undergoing noncardiac surgery (ROC AUC 0.91; 95% CI 0.83-0.99; P<0.001).
Cohort (n=44)
Do preoperative Brain Natriuretic Peptide (BNP) levels predict perioperative events in cardiac patients undergoing noncardiac surgery?
Preoperative BNP measurement provides strong prognostic value for predicting 30-day perioperative cardiac complications in high-risk cardiac patients undergoing noncardiac surgery.
Effect estimate: ROC AUC 0.91 (95% CI 0.83-0.99)
p-value: p=< 0.001
OBJECTIVES: Brain natriuretic peptide (BNP) levels correlate with prognosis in patients with cardiac disease and may be useful in the risk stratification of cardiac patients undergoing noncardiac surgery (NCS). The objective of this study was to examine whether BNP levels predict perioperative events in cardiac patients undergoing NCS. METHODS: Patients undergoing NCS with at least 1 of the following criteria were included: a clinical history of congestive heart failure (CHF), ejection fraction 165 pg/ml (100% sensitivity, 70% specificity). CONCLUSIONS: BNP levels may predict perioperative complications in cardiac patients undergoing NCS, and the measurement of BNP should be considered to assess the preoperative cardiac risk.
Leibowitz et al. (2007) conducted a cohort in Cardiac patients undergoing noncardiac surgery (n=44). Brain natriuretic peptide (BNP) measurement was evaluated on Death, myocardial infarction or pulmonary congestion requiring intravenous diuretics at 30 days (ROC AUC 0.91, 95% CI 0.83-0.99, p=< 0.001). Preoperative BNP levels strongly predicted 30-day perioperative complications in cardiac patients undergoing noncardiac surgery (ROC AUC 0.91; 95% CI 0.83-0.99; P<0.001).