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October 26, 2019British Journal of Pharmacology138 citationsOpen Access

CuII(atsm) inhibits ferroptosis: Implications for treatment of neurodegenerative disease

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ASAdam SouthonKSKathryn SzostakKAKarla Acevedo

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Abstract

BACKGROUND AND PURPOSE: (atsm) to inhibit ferroptosis. EXPERIMENTAL APPROACH: (atsm) was compared to the known antiferroptotic compound liproxstatin-1. KEY RESULTS: -induced lipid peroxidation, consistent with these compounds quenching lipid radicals. CONCLUSIONS AND IMPLICATIONS: (atsm) possesses favourable properties such as oral bioavailability and entry into the brain that make it an attractive investigational product for clinical trials of ferroptosis-related diseases.

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Cite This Study

Southon et al. (2019) studied this question.

synapsesocial.com/papers/6a053eff8bc215e9180b04d2https://doi.org/10.1111/bph.14881
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