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May 14, 2026Journal of Agricultural and Food Chemistry1 citations

Computationally and Target-Guided Discovery of Trifluoromethyl-Pyrazole Derivatives Targeting the a–c Subunit Interface of V-ATPase in Phytophthora capsici

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XLXingxing LuPlant Protection InstituteXLXinxin LiPlant Protection InstituteXWXixi WangPlant Protection Institute

Key Points

  • The aim is to discover new compounds that inhibit the V-ATPase enzyme in Phytophthora capsici.
  • Computational screening of trifluoromethyl-pyrazole derivatives
  • Targeting the a–c subunit interface of V-ATPase
  • In vitro testing of compound efficacy against Phytophthora capsici.
  • Identified several promising trifluoromethyl-pyrazole derivatives with inhibitory effects on V-ATPase.
  • Demonstrated effective binding at the a–c subunit interface with potential applications.
  • Effectiveness varies among derivatives, indicating pathways for optimization.

Abstract

Vacuolar H

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Cite This Study

Lu et al. (2026) studied this question.

synapsesocial.com/papers/6a05659da550a87e60a1df28https://doi.org/10.1021/acs.jafc.6c02464
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