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May 14, 2026Angewandte Chemie International Edition0 citations

Metallaphotoredox‐Catalyzed Acceptorless Dehydrogenative Carbonylation Employing Benzylic C─H Bonds as Limiting Substrates

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LLLing LiCTChuqian TangGHGuangying Huang

Key Points

  • The study aims to explore a novel carbonylation reaction using benzylic C─H bonds as substrates.
  • Utilized metallaphotoredox catalysis for carbonylation reactions
  • Investigated diverse substrates with various functional groups
  • Conducted mechanistic studies to elucidate reaction pathways
  • Achieved broad substrate scope with significant tolerance for complex bioactive scaffolds
  • Demonstrated effective photoinduced hydrogen atom transfer
  • Evidence supports nickel-mediated pathways as a mechanism of action

Abstract

as the sole byproduct. The reaction exhibits broad substrate scope, tolerating diverse functional groups and complex bioactive scaffolds. Mechanistic studies are consistent with a pathway involving photoinduced hydrogen atom transfer and nickel-mediated carbonylation.

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Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a05685ca550a87e60a20d52https://doi.org/10.1002/anie.9220846
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metallaphotoredox‐Catalyzed Acceptorless Dehydrogenative Carbonylation Employing Benzylic C─H Bonds as Limiting Substrates2026
  2. 2Catalyst‐Controlled Chemodivergent Carbene Transfer Reactions With Bicyclo[1.1.0]butane‐Derived Acceptor Metallocarbenes2026
  3. 3Catalyst-Controlled Chemodivergent Carbene Transfer Reactions With Bicyclo[1.1.0]butane-Derived Acceptor Metallocarbenes.2026
  4. 4Migratory C(sp <sup>2</sup> )–H/C(sp <sup>3</sup> )–H Cross‐Coupling Enabled by Metallaphotoredox Catalysis2025 · 3 citations
  5. 5Organocatalytic Acceptorless Dehydrogenation of Alcohols2026