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June 1, 1978Circulation

QT interval prolongation as predictor of sudden death in patients with myocardial infarction.

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Why the study?

Does QTc prolongation predict sudden cardiac death in patients with recent myocardial infarction?

Population

55 patients with recent myocardial infarction and 55 healthy controls, matched for age, sex, race, height…

Comparison

Prolonged QTc interval vs Normal QTc interval

Design

Cohort

Follow-up

7 years

Key result

A prolonged QTc interval in patients with recent myocardial infarction was associated with a 2.16 times greater risk of sudden cardiac death over 7 years (P<0.01).

Authors

PSPeter J. SchwartzSWSharon G. Wolf

Discussion

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Overview

QTc prolongation may flag higher sudden death risk post-MI; leaves open incremental value for risk stratification or intervention.

Key Points

  • This research aims to determine if prolonged QT interval can predict sudden death in myocardial infarction patients.
  • Matched 55 myocardial infarction patients with 55 healthy controls by various demographic factors.
  • Conducted electrocardiograms every two months over seven years.
  • Monitored sudden cardiac death occurrences in both groups.
  • Prolonged QTc was seen in 57% of patients who had sudden death compared to 18% of surviving patients (P < 0.01).
  • Only one control out of 55 had a prolonged QTc and experienced sudden death.
  • Risk of sudden death was 2.16 times higher among patients with prolonged QTc.

Study Design

Type

Cohort (n=110)

Structured PICO

Does QTc prolongation predict sudden cardiac death in patients with recent myocardial infarction?

P
Population
55 patients with recent myocardial infarction and 55 healthy controls, matched for age, sex, race, height, weight, education, and job
I
Intervention
Prolonged QTc interval
C
Comparator
Normal QTc interval
O
Outcome
Sudden cardiac deathhard clinical

Main Result

Effect estimate: RR 2.16

p-value: p=<0.01

A constant prolongation of the QTc interval in patients with a recent myocardial infarction is a significant predictor of sudden cardiac death.

Cite This Study

Schwartz et al. (1978) conducted a cohort in Recent myocardial infarction (n=110). Prolonged QTc interval vs. Normal QTc interval was evaluated on Sudden cardiac death (RR 2.16, p=<0.01). A prolonged QTc interval in patients with recent myocardial infarction was associated with a 2.16 times greater risk of sudden cardiac death over 7 years (P<0.01).

synapsesocial.com/papers/6a0662fd3f8bf83a443dd9d1https://doi.org/10.1161/01.cir.57.6.1074
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