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May 15, 2026Acta Paediatrica0 citations

Pattern and Predictors of Bronchopulmonary Dysplasia in Preterm Infants in New South Wales, Australia: A Population‐Based Cohort Study

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SMSyeda Mah‐E‐MuneerJKJahidur Rahman KhanMCMei Chan

Key Points

  • To examine the patterns and predictors of bronchopulmonary dysplasia and mortality in preterm infants in Australia.
  • Retrospective population study using linked statewide health administrative data (2005-2015).
  • Estimated incidence of BPD, death, and composite outcomes stratified by gestational age.
  • Utilized generalized estimating equation logistic regression models to analyze associated risk factors.
  • Among 73,314 preterm infants, 1,898 developed BPD (25.9/1000).
  • Incidence of BPD was highest in extremely preterm infants at 324.6/1000; annual incidence increased from 23.5 to 28.0/1000 (p < 0.001).
  • BPD risk factors included extreme prematurity (aOR 8.5-13.35), small-for-gestational-age (aOR 3.27-3.88), and low 5-min APGAR scores (aOR 1.64-12.47).

Abstract

AIM: To examine the population pattern of bronchopulmonary dysplasia (BPD), death and composite outcome (BPD/death) in preterm infants in Australia. METHODS: A retrospective population study using linked statewide health administrative data between 2005 and 2015 to estimate the incidence of BPD, death and composite outcome stratified by gestation: extremely preterm (EPT), very preterm (VPT) and moderate-to-late preterm (MPT). Associated risk factors were analysed using generalized estimating equation logistic regression models. RESULTS: Of 1 047 885 live births, 73 314 (7%) were preterm, of whom 1906 died and 1898 developed BPD (25.9/1000). BPD incidence was highest in EPT (324.6/1000), followed by VPT (89.7/1000) and MPT (1.5/1000) infants. Annual BPD incidence increased from 23.5 (in 2005) to 28.0/1000 (in 2015) (p < 0.001), while composite outcome marginally decreased from 55.3 to 46.3/1000 (p = 0.629), driven by reduced mortality (32.5 to 18.8/1000) (p < 0.001). Among 10 407 < 32 weeks infants, risk factors for BPD, death and composite outcomes were born EPT (aOR ranging 8.5-13.35), assisted vaginal/breech delivery (aOR 1.25-1.41), small-for-gestational-age (aOR 3.27-3.88), male sex (aOR 1.21-1.42) and had low 5-min APGAR score (aOR 1.64-12.47). CONCLUSION: The rising BPD incidence, predominantly among EPT survivors, was offset by reduced overall preterm mortality. Findings call for healthcare planning to cater for increased BPD survivors.

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Cite This Study

Mah‐E‐Muneer et al. (2026) studied this question.

synapsesocial.com/papers/6a06b8dfe7dec685947ab695https://doi.org/10.1111/apa.70596
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