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September 1, 1998Hypertension168 citations

Relation Between Coronary Artery Disease, Aortic Stiffness, and Left Ventricular Structure

Relation Between Coronary Artery Disease, Aortic Stiffness, and Left Ventricular Structure in a Population Sample

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Why the study?

Is previously unknown coronary artery disease associated with increased aortic stiffness and altered left ventricular structure compared to matched controls?

Population

110 subjects from a healthy general population sample, comprising 55 subjects with previously unknown…

Comparison

Presence of previously unknown coronary artery… vs Control subjects matched for gender, age, and…

Design

Case-control

Key result

Newly diagnosed coronary artery disease was associated with significantly higher aortic stiffness (Ep 212 vs 123 kN/m2; P<0.01) and left ventricular mass index compared to matched healthy controls.

Authors

CGChristoph D. GatzkaJCJames D. CameronBKBronwyn A. Kingwell

Discussion

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Overview

No immediate practice change; extends observational links to new CAD but leaves causal role and interventions open.

Key Points

  • This research aims to clarify the connections between coronary artery disease, aortic stiffness, and left ventricular structure.
  • Analyzed 55 subjects with newly diagnosed coronary artery disease and 55 matched controls.
  • Measured arterial blood pressure and aortic stiffness using echocardiography.
  • Compared left ventricular mass index between CAD patients and controls.
  • CAD patients had significantly higher aortic stiffness (Ep: 212 vs. 123 kN/m2, P<0.01).
  • Majority of CAD patients (61%) were in the highest stiffness quartile compared to controls (P<0.05).
  • Left ventricular mass index in CAD patients was higher (139 vs. 123 g/m2, P<0.05).

Study Design

Type

Case-Control (n=110)

Structured PICO

Is previously unknown coronary artery disease associated with increased aortic stiffness and altered left ventricular structure compared to matched controls?

P
Population
110 subjects from a healthy general population sample, comprising 55 subjects with previously unknown coronary artery disease (CAD) (33 men; average age, 63+/-1 years) and 55 control subjects matched for gender, age, and serum cholesterol level.
I
Intervention
Presence of previously unknown coronary artery disease (CAD)
C
Comparator
Control subjects matched for gender, age, and serum cholesterol level
O
Outcome
Aortic stiffness (measured by brachial pulse pressure and stiffness indices Ep and beat) and left ventricular structure (left ventricular mass index) assessed by echocardiographysurrogate

Newly diagnosed coronary artery disease is associated with increased aortic stiffness and left ventricular mass, which may help explain the link between elevated pulse pressure and cardiovascular mortality.

Main Result

Absolute Event Rate: 212% vs 123%

p-value: p=<0.01

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Cite This Study

Gatzka et al. (1998) conducted a case-control in Coronary artery disease (n=110). Coronary artery disease vs. Matched healthy controls was evaluated on Aortic stiffness index (Ep) (p=<0.01). Newly diagnosed coronary artery disease was associated with significantly higher aortic stiffness (Ep 212 vs 123 kN/m2; P<0.01) and left ventricular mass index compared to matched healthy controls.

synapsesocial.com/papers/6a07b4da44ff8ad339f69c45https://doi.org/10.1161/01.hyp.32.3.575
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