Higher baseline arterial stiffness (cf-PWV) was associated with a higher risk of MACEs in individuals with mildly impaired renal function (HR 2.334; 95% CI 1.082-5.036; P=0.031).
Cohort (n=1,499)
Does higher arterial stiffness predict major adverse cardiovascular events in individuals with mildly impaired renal function?
Arterial stiffness measured by cf-PWV is an independent predictor of MACE in patients with mildly impaired renal function, suggesting its utility for cardiovascular risk stratification in this population.
Effect estimate: HR 2.334 (95% CI 1.082-5.036)
p-value: p=0.031
OBJECTIVES: Despite growing evidence that arterial stiffness has important predictive value for cardiovascular disease in patients with advanced stages of chronic kidney disease, the predictive significance of arterial stiffness in individuals with mildly impaired renal function has not been established. The aim of this study was to evaluate the predictive value of arterial stiffness on cardiovascular disease in this specific population. MATERIALS AND METHODS: We analyzed measurements of arterial stiffness (carotid-femoral pulse-wave velocity cf-PWV) and the incidence of major adverse cardiovascular events (MACEs) in 1,499 subjects from a 4.8-year longitudinal study. RESULTS: A multivariate Cox proportional-hazard regression analysis showed that in individuals with normal renal function (estimated glomerular filtration rate eGFR ≥90 mL/min/1.73 m(2)), the baseline cf-PWV was not associated with occurrence of MACEs (hazard ratio 1.398, 95% confidence interval 0.748-2.613; P=0.293). In individuals with mildly impaired renal function (eGFR <90 mL/min/1.73 m(2)), a higher baseline cf-PWV level was associated with a higher risk of MACEs (hazard ratio 2.334, 95% confidence interval 1.082-5.036; P=0.031). CONCLUSION: Arterial stiffness is a moderate and independent predictive factor for MACEs in individuals with mildly impaired renal function (eGFR <90 mL/min/1.73 m(2)).
Ye et al. (2016) conducted a cohort in Mildly impaired renal function (n=1,499). Arterial stiffness (cf-PWV) vs. Lower baseline cf-PWV was evaluated on Major adverse cardiovascular events (MACEs) (HR 2.334, 95% CI 1.082-5.036, p=0.031). Higher baseline arterial stiffness (cf-PWV) was associated with a higher risk of MACEs in individuals with mildly impaired renal function (HR 2.334; 95% CI 1.082-5.036; P=0.031).