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May 16, 2026Journal of Agricultural and Food Chemistry0 citations

Xylanase and Wheat Bran Improve Obesity and Metabolism in Mice

Ameliorating High-Fat Diet-Induced Obesity and Metabolic Disorders in Mice by Simultaneous Oral Administration of a Xylanase and Wheat Bran

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Authors

ZHZhenzhen HaoJGJianzhong GeYSYanpeng Sun

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Overview

Randomized trial shows improved lipid metabolism in mice with high-fat diet when given xylanase and wheat bran, indicating a promising dietary strategy.

Key Points

  • The aim is to investigate the effects of xylanase and wheat bran on obesity and metabolic disorders in mice.
  • Mice were administered xylanase and wheat bran concurrently.
  • Changes in lipid metabolism and gut microbiota were analyzed.
  • Spearman analysis assessed associations between gut microbes, metabolites, and obesity indicators.
  • Co-administration significantly improved steroid hormone biosynthesis and sphingolipid levels.
  • A strong association was found between gut microbes and obesity-related indicators.
  • The strategy effectively alleviated high-fat diet-induced obesity in mice.

Cite This Study

Hao et al. (2026) studied this question.

synapsesocial.com/papers/6a0808ffa487c87a6a40b1e8https://doi.org/10.1021/acs.jafc.5c17603
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