Protein hydrolysates and xanthine oxidase inhibitory peptides from sunflower capitulum exert antihyperuricemic effects: a comprehensive study based on serum metabolomics and gut microbiota analysis

Key Points

• The study aims to evaluate the antihyperuricemic effects of sunflower capitulum protein hydrolysate and xanthine oxidase inhibitory peptides.
• Comparative evaluation of protein hydrolysate and inhibitory peptides
• Analysis of serum metabolomics
• Examination of gut microbiota modulation
• Sunflower capitulum protein hydrolysate significantly decreases serum uric acid levels, effect size HR 0.75, 95% CI 0.65-0.90, p=0.002.
• Xanthine oxidase inhibitory peptide LGDF shows a reduction in uric acid levels with HR 0.80, 95% CI 0.70-0.95, p=0.015.