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May 16, 2026Indian Journal of Nuclear Medicine0 citationsOpen Access

Testicular Metastasis from Urothelial Carcinoma of the Renal Pelvis Detected on 18 F-FDG PET/CT: A Rare Case

SKSantosh C. KannurAll India Institute of Medical Sciences BhubaneswarTST Kishan SubudhiAll India Institute of Medical Sciences BhubaneswarGPGirish Kumar ParidaAll India Institute of Medical Sciences Bhubaneswar

Key Points

  • This case highlights the rarity of testicular metastasis due to urothelial carcinoma and underscores the utility of advanced imaging for detection.
  • Reported case of a 61-year-old male with renal pelvis carcinoma and extensive metastasis detected via whole-body FDG PET/CT.
  • Biopsy of a liver lesion confirmed metastatic carcinoma with immunohistochemistry showing urothelial origin.
  • FDG PET/CT identified an unusual FDG-avid right testicular mass alongside other metastatic sites.
  • Renal pelvis mass with renal vein thrombus indicated significant advanced disease stage.

Abstract

Renal pelvis carcinoma and renal cell carcinoma are known for their unpredictable metastatic behaviour. While lungs, liver, bones, and lymph nodes are common sites of spread, testicular metastasis is exceptionally rare. We report a 61-year-old male who presented with painless haematuria and was found to have a left renal pelvis mass with renal vein thrombus. Whole-body 18 F- Fluorodeoxyglucose (FDG) PET/CT demonstrated extensive metastatic disease involving the lungs, liver, adrenal gland, multiple nodal groups, vertebrae, and an unusual FDG-avid right testicular mass. Ultrasound-guided biopsy of a liver lesion confirmed metastatic carcinoma, with immunohistochemistry favouring a urothelial origin. This case highlights the value of FDG PET/CT in the comprehensive staging of advanced renal malignancies and emphasises awareness of rare metastatic sites such as the testis, which may significantly impact staging, prognosis, and therapeutic decision-making.

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Cite This Study

Kannur et al. (2026) studied this question.

synapsesocial.com/papers/6a080acea487c87a6a40cd66https://doi.org/10.25259/ijnm_19_2026
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1European Association of Urology Guidelines on Renal Cell Carcinoma: The 2022 Update2022 · 1,538 citations
  2. 2PET/Computed Tomography in Renal, Bladder, and Testicular Cancer2015 · 37 citations
  3. 3Testicular Metastasis from Renal Cell Carcinoma: A Case Report and Review of the Literature2017 · 16 citations
  4. 4European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2017 Update2017 · 778 citations
  5. 5Metastatic Carcinoma to the Testis2008 · 148 citations