Lipoma of the corpus callosum is a rare congenital malformation of the central nervous system and is seldom encountered in clinical practice. These lesions are most often discovered incidentally during neuroimaging performed for unrelated clinical indications. We report the case of a male neonate presenting with transient hypotonia, in whom a congenital lipoma of the corpus callosum was identified on imaging. The diagnosis was established using cranial ultrasonography followed by magnetic resonance imaging. The clinical course was favorable, with spontaneous resolution of hypotonia under conservative management. This case highlights the role of ultrasound and MRI in the diagnosis of congenital intracranial lipomas and the typically benign course of isolated corpus callosum lipomas.
Rania et al. (2026) studied this question.