In asymptomatic healthy individuals, the frequency of atrial (OR 1.059) and ventricular arrhythmias (OR 1.023) increased with age, and transient AV block was more frequent with resting HR <60 bpm.
Cohort (n=625)
In asymptomatic healthy individuals, the frequency of atrial and ventricular arrhythmias on 24-hour Holter monitoring increases with age, while transient Mobitz I AV block is associated with a resting heart rate <60 bpm.
Effect estimate: OR 1.059 (95% CI 1.050-1068)
p-value: p=<0.0001
AIMS: To evaluate cardiac arrhythmias and rhythm disturbances on 24 h ambulatory electrocardiographic monitoring in a cohort of asymptomatic healthy individuals with normal clinical examination. METHODS AND RESULTS: 625 asymptomatic healthy individuals, in the age range 15-83 (mean 42, SD 11.9) years; 276 (44.2%) men and 349 (55.8%) women were submitted to 24-hour ambulatory electrocardiographic monitoring. Statistical analysis was performed with likelihood ratio test and automatic backward logistic regression. The frequency of atrial arrhythmias (p < 0.0001; OR 1.059; 95% CI 1.050-1068) and of ventricular arrhythmias (p < 0.0001; OR 1.023; 95% CI 1.017-1.029) increased for each age increase of 1 year; neither atrial nor ventricular arrhythmias demonstrated a statistically significant difference relative to gender. Transient second-degree atrioventricular block (Mobitz I) was observed in 14 (2.2%) individuals and was more frequent in individuals with resting heart rate <60 bpm (p = 0.006; OR 6.7, 95% CI 1.7-25.5). CONCLUSION: The frequency of atrial and ventricular arrhythmias increased with age and did not demonstrate a significant difference relative to gender. Transient atrioventricular block was more frequent in individuals with lower resting heart rate.
DePaula et al. (2006) conducted a cohort in Asymptomatic healthy individuals without heart disease (n=625). 24-hour ambulatory electrocardiographic monitoring was evaluated on Frequency of atrial arrhythmias per 1-year increase in age (OR 1.059, 95% CI 1.050-1068, p=<0.0001). In asymptomatic healthy individuals, the frequency of atrial (OR 1.059) and ventricular arrhythmias (OR 1.023) increased with age, and transient AV block was more frequent with resting HR <60 bpm.