Multimodality tissue tracking (MTT) correlated closely with SENC-MRI for quantifying right ventricular global longitudinal strain (r=0.72, p<0.001) in pulmonary hypertension patients.
Observational (n=45)
Does multimodality tissue tracking (MTT) accurately measure bi-ventricular strain compared to SENC and HARP MRI in patients with pulmonary hypertension?
Multimodality tissue tracking is a reproducible tool for quantifying cardiac deformation using cine MRI in pulmonary hypertension patients, correlating well with established MRI strain techniques.
Effect estimate: r=0.72
p-value: p=<0.001
BACKGROUND: Pixel-based multimodality tissue tracking (MTT) is a new noninvasive method for the quantification of cardiac deformation from cine image of MRI. The aim of this study is to validate bi-ventricular strain measurement by MTT compared to strain-encoding (SENC) MRI and harmonic phase (HARP) MRI in pulmonary hypertension (PH) patients. METHODS: In 45 subjects (30 PH patients and 15 normal subjects), RV and LV peak global longitudinal strains (Ell) were measured from long axis 4 chamber view using MTT. LV peak global circumferential strains (Ecc) by MTT were measured from short axis. For validation, RV and LV Ell by MTT were compared to measures by SENC-MRI from short axis, and LV Ecc by MTT was compared to measures by short axis tagged MRI analysis (HARP). Reproducibility of MTT was also determined. RESULTS: MTT quantified RV Ell correlated closely to those of SENC (r=0.72, p<0.001), with good limits of agreement. LV Ell quantified by MTT showed moderate correlation with SENC (r=0.57, p=0.001), and LV Ecc by MTT also showed moderate correlation with HARP (-16.9±4.1 vs -14.3±3.5, p<0.001 for all, r=0.60, p<0.001). RV Ell negatively correlated with RVEF (r=-0.53, p=0.001) and also positively correlated with mean PAP in PH patients (r=0.60, p=0.001). Strain measurement by MTT showed high reproducibility. CONCLUSIONS: We demonstrate that MTT is a reproducible tool for quantification of cardiac deformation using cine images in PH patients. Hence, it could serve as a new rapid and comprehensive technique for clinical assessment of regional cardiac function.
Ohyama et al. (2015) conducted an observational in Pulmonary hypertension (n=45). Multimodality tissue tracking (MTT) vs. Strain-encoding (SENC) MRI and harmonic phase (HARP) MRI was evaluated on Correlation of RV peak global longitudinal strain (Ell) between MTT and SENC-MRI (r=0.72, p=<0.001). Multimodality tissue tracking (MTT) correlated closely with SENC-MRI for quantifying right ventricular global longitudinal strain (r=0.72, p<0.001) in pulmonary hypertension patients.