Lower myocardial flow reserve was associated with reduced regional left ventricular function in asymptomatic individuals, with an absolute decrease in global Ecc of 2.8% (P<0.05).
Observational (n=74)
Yes
Is lower myocardial perfusion reserve associated with decreased regional left ventricular function in asymptomatic individuals?
Lower myocardial flow reserve is associated with reduced regional left ventricular function in asymptomatic individuals without clinical heart disease.
p-value: p=<0.05
BACKGROUND: Myocardial ischemia is an important determinant of regional left ventricular systolic function. Myocardial blood flow reserve may be impaired by cardiovascular disease before alterations of myocardial perfusion at rest become manifest. Nevertheless, the relation between flow reserve and regional myocardial function has not been studied in individuals without a history of clinical heart disease. METHODS AND RESULTS: Seventy-four participants (66+/-9 years, mean+/-SD) of the Multi-Ethnic Study of Atherosclerosis (MESA) underwent myocardial magnetic resonance tagging and contrast-enhanced perfusion studies. Regional myocardial function was evaluated as peak systolic circumferential strain (Ecc) in the three main coronary territories (left anterior descending LAD, left circumflex, and right coronary artery RCA). Myocardial blood flow at rest and during adenosine-induced hyperemia was quantified by contrast-enhanced magnetic resonance imaging, to study the relation between regional flow and function after multivariable adjustment for age, gender, body mass index, left ventricular mass, and traditional risk factors. Lower regional myocardial blood flow during hyperemia was associated with reduced regional left ventricular function expressed as lower Ecc in the RCA (P<0.01) and left circumflex regions (P<0.05) measured in the subendocardium, mid-wall, and subepicardium. In contrast, no significant association was seen in the LAD territory (P=0.16). In addition, segmental function in LAD and RCA regions was reduced when individuals in the lowest 10th percentile for regional myocardial flow reserve were compared with the other participants. Absolute decreases in mid-wall Ecc LAD and RCA and global Ecc were 3.0%, 3.4%, and 2.8%, respectively (P<0.05 for all regions). CONCLUSIONS: Lower myocardial flow reserve is related to reduced regional function in asymptomatic individuals.
Rosen et al. (2006) conducted an observational in Asymptomatic individuals without clinical heart disease (n=74). Lower myocardial flow reserve (lowest 10th percentile) vs. Higher myocardial flow reserve (>10th percentile) was evaluated on Regional myocardial function evaluated as peak systolic circumferential strain (Ecc) (p=<0.05). Lower myocardial flow reserve was associated with reduced regional left ventricular function in asymptomatic individuals, with an absolute decrease in global Ecc of 2.8% (P<0.05).