Systematic histopathologic evaluation of Type-A aortic dissections suggests a triple-hit causation mechanism involving an intimal tear, diseased media, and tear propagation (p=0.005).
Observational
Type-A aortic dissection may be caused by a uniform triple-hit mechanism involving an intimal tear, a diseased media, and propagation towards the vasa vasorum.
p-value: p== 0.005
= 0.005). (4) Conclusions: On the basis of the systematic evaluation and the consistent presence of diffuse, pre-existing medial defects, we hypothesize that TAAD relates to a developmental defect of the ascending aorta and is caused by a triple-hit mechanism that involves (I) an intimal tear; and (II) a diseased media, which allows (III) propagation of the tear towards the plane of the vasa vasorum where the dissection further progresses.
Grewal et al. (2021) conducted an observational in Type-A Aortic Dissections. Systematic histopathologic evaluation of Type-A aortic dissections suggests a triple-hit causation mechanism involving an intimal tear, diseased media, and tear propagation (p=0.005).