Key points are not available for this paper at this time.
Short and to the point: A formal synthesis of platensimycin has been accomplished by employing a carbonyl ylide 3+2 cycloaddition reaction (see scheme). This short and facile enantioselective synthesis of the pivotal tetracyclic precursor requires 11 steps and proceeds in 20 % overall yield from isopropyl cyanoacetate. Supporting information for this article is available on the WWW under http: //www. wiley-vch. de/contents/jc₂002/2008/z800568ₛ. pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Kim et al. (2008) studied this question.