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January 1, 1987Biometrika177 citationsOpen Access

A simple test of the proportional hazards assumption

RGRichard D. GillMSMartin Schumacher

Key Points

  • To present a new test of the proportional hazards assumption for censored data and assess its strengths and weaknesses.
  • Introduced a new comparison method of generalized rank estimators of relative risk.
  • Demonstrated asymptotic normality and consistency against monotone hazard ratio alternatives.
  • Presented a graphical method alongside recommendations for weight function choices.
  • Illustrated strengths and weaknesses via four examples relevant to clinical research, showing varied situations.
  • Demonstrated the test's applicability and effectiveness in assessing the proportional hazards assumption.

Abstract

A new test of the proportional hazards assumption for two-sample censored data is presented. The test is based on a comparison of different generalized rank estimators of the relative risk. Asymptotic normality and consistency against alternatives with monotone hazard ratio are shown and relationships to other proposals are pointed out. A related graphical method is presented and recommendations for the choice of appropriate weight functions are given. The strengths and weaknesses of the test procedure proposed are illustrated by four examples featuring various situations which are of practical importance in clinical research.

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Cite This Study

Gill et al. (1987) studied this question.

synapsesocial.com/papers/6a0899d4113ba5b476de519chttps://doi.org/10.1093/biomet/74.2.289
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A class of rank test procedures for censored survival data1982 · 1,183 citations
  2. 2Hazard Plotting for Incomplete Failure Data1969 · 533 citations
  3. 3A Two-Sample Censored-Data Rank Test for Acceleration1984 · 108 citations
  4. 4A graphical method for comparing trends in series of events1981 · 21 citations
  5. 5Goodness of fit methods for the proportional hazards regression model: a review.1984 · 61 citations