Evaluating the feasibility of 12-lead electrocardiogram reconstruction from limited leads using deep learning

Abstract Background Wearables with integrated electrocardiogram (ECG) acquisition have made single-lead ECGs widely accessible to patients and consumers. However, the 12-lead ECG remains the gold standard for most clinical cardiac assessments. In this study, we developed a neural network to reconstruct 12-lead ECGs from single-lead and dual-lead ECGs, and evaluated the mathematical accuracy. Methods We used lead I or leads I and II from 9514 individuals from the Physikalisch-Technische Bundesanstalt (PTB-XL) cohort and a generative adversarial network, with the aim of recreating the missing leads from the 12-lead ECG. ECGs were divided into training, validation, and testing (10%). Original and recreated leads were measured with a commercially available algorithm. Differences in means and variances were assessed with Student’s t-tests and F-tests, respectively. Calibration and bias were assessed with Bland-Altman plots. Inter-lead correlations were compared in original and recreated ECGs. Results The variability of precordial ECG amplitudes is significantly reduced in recreated ECGs compared to real ECGs (all p < 0.05), indicating regression-to-the-mean. Amplitude averages are recreated with bias ( p < 0.05 for most leads). Reconstruction errors depend on the real amplitudes, suggesting regression-to-the-mean ( R 2 between target and error in R-peak amplitude in lead V3: 0.92). The relations between lead markers have a similar slope but are much stronger due to reduced variance (R-peak amplitude R 2 between leads I and V3, real ECGs: 0.04, recreated ECGs: 0.49). Using two leads does not significantly improve 12-lead recreation. Conclusions AI-based 12-lead ECG reconstruction results in a regression-to-the-mean effect rather than personalized output, rendering it unsuitable for clinical use.