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The success or failure of antimicrobial therapy in bacterial and fungal infections is predicted ideally by antimicrobial susceptibility testing (AST), in which microorganisms are divided into treatable and non-treatable categories on the basis of MIC breakpoints. In Europe, the categorization was traditionally a clinical one and it was made irre-spective of whether or not the organism harboured resistance mechanisms. MIC breakpoints generally divide bacteria into three
Gunnar Kahlmeter (2003) studied this question.