A single measurement of circulating troponin T 72 hours after onset of chest pain correlated significantly with infarct size, proving superior to peak CK, CK-MB, or LDH independent of reperfusion.
Observational (n=37)
Does a single measurement of troponin T 72 hours after myocardial infarction accurately estimate infarct size compared to standard enzymatic estimates?
A single measurement of troponin T at 72 hours post-myocardial infarction provides a superior estimate of infarct size compared to peak CK, CK-MB, or LDH, as it does not require serial determinations and is independent of reperfusion.
BACKGROUND: After acute myocardial infarction, the structural protein T is released considerably longer than cytosolic creatine kinase (CK), CK MB isoenzyme (CK-MB), or lactate dehydrogenase (LDH) and late troponin T release (> 48 hours after onset of chest pain) appears to be less affected by early coronary reperfusion. OBJECTIVE: To investigate the precision of a single measurement of circulating troponin T concentrations 72 hours after onset of chest pain compared with standard scintigraphic and enzymatic estimates of myocardial infarct size. METHODS: Quantitative single photon emission computed tomography thallium-201 scintigraphy at rest was performed in 37 patients 2-3 weeks after myocardial infarction (group 1: 14 patients without early coronary reperfusion; group 2: 23 patients with early reperfusion achieved by thrombolytic therapy, by percutaneous transluminal coronary angioplasty, or by both). RESULTS: In both groups, the number of myocardial segments with abnormal thallium-201 uptake indicating the individual extent of irreversible myocardial damage correlated significantly with the troponin T concentrations 72 hours after infarction as well as with peak concentrations of CK, CK-MB, and LDH. CONCLUSION: The data show that a single measurement of circulating troponin T 72 hours after onset of chest pain--independent of reperfusion--is superior for the estimation of myocardial infarct size to measurement of peak CK, CK-MB, or LDH, which require serial determinations and depend on coronary reperfusion.
Manuela Licka (2002) conducted an observational in Acute myocardial infarction (n=37). Single measurement of circulating troponin T at 72 hours vs. Peak CK, CK-MB, or LDH was evaluated on Correlation with the number of myocardial segments with abnormal thallium-201 uptake indicating irreversible myocardial damage. A single measurement of circulating troponin T 72 hours after onset of chest pain correlated significantly with infarct size, proving superior to peak CK, CK-MB, or LDH independent of reperfusion.