Obese female subjects expressed approximately twofold more TNFR2 mRNA in fat tissue and sixfold more soluble TNFR2 in circulation relative to lean controls, correlating with BMI (r=0.65, P<0.001).
Observational
Is the expression of TNF receptors (TNFR1 and TNFR2) altered in human obesity?
TNFR2 expression is upregulated in human obesity and correlates with BMI and insulin resistance, suggesting a role in modulating TNF-alpha actions.
Effect estimate: r = 0.65
p-value: p=<0.001
Previous studies have shown that tumor necrosis factor (TNF)-alpha production from adipose tissue is elevated in rodent and human obesity and plays an important role in insulin resistance in experimental animal models. In this study, we examined the adipose expression of both TNF receptors (TNFR1 and TNFR2) in human obesity and demonstrated that obese female subjects express approximately twofold more TNFR2 mRNA in fat tissue and approximately sixfold more soluble TNFR2 in circulation relative to lean control subjects. In contrast, TNFR1 expression and protein levels were similar in these subjects. TNFR2 expression levels in adipose tissue were strongly correlated with BMI (r = 0.65, P < 0.001) and level of hyperinsulinemia (P < 0.001), an indirect measure of insulin resistance, as well as level of TNF-alpha mRNA expression in fat tissue (r = 0.56, P < 0.001). These results suggest that TNFR2 might play a role in human obesity by modulating the actions of TNF-alpha.
Hotamışlıgil et al. (1997) conducted an observational in Obesity and insulin resistance. Obesity vs. Lean control subjects was evaluated on TNFR2 expression levels in adipose tissue (r = 0.65, p=<0.001). Obese female subjects expressed approximately twofold more TNFR2 mRNA in fat tissue and sixfold more soluble TNFR2 in circulation relative to lean controls, correlating with BMI (r=0.65, P<0.001).