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May 17, 2026PLoS ONE0 citationsOpen Access

Expression of Concern: Signaling Networks Associated with AKT Activation in Non-Small Cell Lung Cancer (NSCLC): New Insights on the Role of Phosphatydil-Inositol-3 kinase

TEThe PLOS One Editors

Key Points

  • The aim is to address concerns regarding the integrity of the published findings on AKT activation signaling in NSCLC.
  • Identification of issues in peer review
  • Concerns raised regarding the quality of figures and panels included in the article.
  • Numerous vertical discontinuities were noted in the figures, specifically in PI3KCA and Tubulin panels of Fig 6B.
  • Vertical discontinuities were also present in AKT1 and Actin panels of Fig S1A.

Abstract

After this article 1 was published, the PLOS One Editors identified concerns about the article's peer review and with Figs 1-6 and S1-S5.Specifically: There appear to be vertical discontinuities between lanes 2 and 3 in the PI3KCAand Tubulin panels of Fig 6B. There appear to be vertical discontinuities between lanes 2 and 3 in the left AKT1 and left Actin panels of Fig S1A.

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Cite This Study

The PLOS One Editors (2026) studied this question.

synapsesocial.com/papers/6a095a877880e6d24efe0718https://doi.org/10.1371/journal.pone.0349359
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