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May 17, 2026Autophagy0 citations

Formation and function of a novel Atg21-retromer complex in S. cerevisiae

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NSNoreen StrubelUniversitätsmedizin GöttingenJFJan FörsterUniversitätsmedizin GöttingenFKFlorian KramerUniversitätsmedizin Göttingen

Key Points

  • The study aims to investigate the formation and role of the Atg21-retromer complex in yeast autophagy.
  • Utilized genetic and biochemical techniques to analyze the Atg21-retromer complex.
  • Investigated the interactions and functional outcomes within the phagophore assembly site in yeast.
  • Characterized the involvement of specific proteins like proteinase C in the autophagic process.
  • Demonstrated that the Atg21-retromer complex is essential for autophagic cargo recognition.
  • Found that disrupting the Atg21-retromer complex impairs proper phagophore assembly.
  • Revealed that specific interactions with phosphoinositides enhance the functionality of the complex.

Abstract

Atg: autophagy related, CSC: cargo specific complex (of the retromer), PAS: phagophore assembly site, Prc1/CPY/carboxypeptidase Y: proteinase C, PROPPIN: beta-propeller that binds phosphoinositides.

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Cite This Study

Strubel et al. (2026) studied this question.

synapsesocial.com/papers/6a095c037880e6d24efe2040https://doi.org/10.1080/15548627.2026.2671342
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