Background Amyotrophic lateral sclerosis (ALS) impairs oral motor function, negatively affecting patients’ speech and swallowing abilities, as well as quality of life. Objective This study aims to evaluate the effectiveness of A Successful Swallowing with Effortful Training (ASSET) program, included in the ‘The 365 Healthy Swallow Health Coach application’ in preserving speech and swallowing abilities in ALS patients through self-training. Methods In this 8-week quasi-experimental study, 13 participants were allocated to either the app-guided ASSET training group (n=7; three sessions per day, five days per week) or a usual-care control group (n=6) based on their clinical visit schedules. To evaluate changes over time and compare the two groups, linear mixed models were employed. Changes in ALS severity scale (ALSSS), Diadochokinetic (DDK) task, speech intensity, Speech Handicap Index-15, Dysphagia Handicap Index, Swallowing Quality of Life (SWAL-QOL), and Brief Inventory of Swallowing Assessment-15 were assessed. Results ALSSS speech scores was relatively preserved from 5.43 (95% CI 3.01–7.84) to 5.29 (95% CI 2.87–7.70) in the ASSET treatment group, but declined from 6.33 (95% CI 3.73–8.94) to 4.83 (95% CI 2.23–7.44) in the control group, with a significant group-by-time interaction (p=.017). DDK/tuh/and/kuh/were relatively preserved from 11.86 to 11.71 and from 12.29 to 11.57 respectively in ASSET group, but declined from 11.67 to 7.50 and from 11.83 to 7.17 in the control group, with significant interactions in/tuh/(p=.032) and/kuh/(p=.044). SWAL-QOL total score was relatively preserved from 155.86 to 149.71 in ASSET group, but declined from 154.67 to 125.17 in the control group, with a significant interaction (p=.011). Conclusions The findings suggest that ASSET program may help preserve speech and swallowing function in patients with ALS. Future research should validate the ASSET program with a larger, adequately powered sample size.
Cho et al. (2026) studied this question.